Multisite Molecules and all-or-none Responses in Cellular Communication

Start: 04/03/2013 - 4:15pm
End  : 04/03/2013 - 5:15pm


German Enciso, University of California, Irvine


Multisite protein modifications are an essential feature of many cellular decision- making processes. It is usually assumed that cooperativity is involved, i.e. the ability of one modified site to increase the rate of modification of its neighbors. I will describe a different set of assumptions to obtain a similar behavior, namely that the individual sites are identical and independent of each other, and that the protein activity is an arbitrary increasing function of the number of modified sites. Under these assumptions I will provide theoretical estimates of the Hill coefficient of the dose response. Examples are provided along with numerical simulations for models of bacterial chemotaxis, the yeast pheromone pathway, the regulation of DNA expression, and a checkpoint in the yeast cell cycle.

Beckman B126, Harvey Mudd College

Enciso.pdf92.83 KB