Do Drugs Reach their Target? A Regularized Stokeslets Model of Tumor Tissue Penetration

Start: 03/13/2013 - 4:15pm
End  : 03/13/2013 - 5:15pm


Kasia Rejniak, Moffitt Cancer Center and Research Institute Mathematical Oncology Department, Tampa, FL


Numerous anti-cancer drugs are being tested in laboratories to see if they will be effec- tive in curing the disease. However, drug efficacy depends not only on their biochemical properties, but also on whether they are able to reach the tumor cells in adequate con- centrations. In order to investigate the transport phenomena of anticancer drugs from the vasculature through the tumor tissue into the cancer cells we developed a computational model that couples the fluid-structure interaction method of regularized Stokeslet with the advection-diffusion-reaction equations. We will discuss several applications of this model, showing how drug penetration can depend on the tissue structure, which affects the advec- tive and diffusive transports. We then use the model to test different scheduling schemes and compare the model results to medical images.
No background in biology or medical imaging will be assumed for this talk.

Beckman B126, Harvey Mudd College

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