Maternal-Fetal Genotype Incompatibility as a Risk Factor for Schizophrenia

Start: 03/01/2012 - 4:15pm
End  : 03/01/2012 - 5:15pm

Statistics/OR/Math Finance Seminar

Christina Palmer


 Prenatal/obstetric complications are implicated in schizophrenia susceptibility. Some complications may arise from maternal-fetal genotype incompatibility, a term used to describe maternal-fetal genotype combinations that produce an adverse prenatal environment. As will be described, maternal-fetal genotype incompatibility can occur when maternal and fetal genotypes differ from one another, or when maternal and fetal genotypes are too similar to each other. Incompatibility genes for each of these scenarios have been implicated as risk factors for schizophrenia and a review of maternal-fetal genotype incompatibility studies suggests that schizophrenia susceptibility is increased by maternal-fetal genotype combinations at the RHD, ABO, and HLA-B loci. Maternal-fetal genotype combinations at these loci are hypothesized to have an effect on the maternal immune system during pregnancy, which can affect fetal neurodevelopment and increase schizophrenia susceptibility. During this presentation, data including recent results from a pedigree analysis will be synthesized and the hypothesized biological role of these incompatibility genes in the etiology of schizophrenia will be described.

Davidson Lecture Hall, Claremont McKenna College

Misc. Information

Professor of Psychiatry and Biobehavioral Sciences, Human Genetics, Institute for Society and Genetics
David Geffen School of Medicine at UCLA