Claremont Center for the Mathematical Sciences

We modify existing models of bacteriophage growth on an
exponentially growing bacterial population by including (1) density
dependent phage attack rates and (2) loss to phage due to adsorption
to both infected and uninfected bacteria. The effects of these
modifications on key pharmacokinetic parameters associated with
phage therapy are examined. More general phage growth models are
explored which account for infection-age of bacteria, bacteria-phage
complex formation, and decoupling phage progeny release from host
cell lysis.