When

Start: 04/30/2018 - 4:15pm

End : 04/30/2018 - 5:15pm

End : 04/30/2018 - 5:15pm

Category

Applied Math Seminar

Speaker

Dominik Wodarz (UC, Irvine)

Abstract

The talk will discuss the use of mathematical models for understanding targeted cancer therapies. One area of focus is the treatment of chronic lymphocytic leukemia with tyrosine kinase inhibitors. I will explore how mathematical approaches have helped elucidate the mechanism of action of the targeted drug ibrutinib, and will discuss how evolutionary models, based on patient-specific parameters, can make individualized predictions about treatment outcomes. Another focus of the talk is the use of oncolytic viruses to kill cancer cells and drive cancers into remission. These are viruses that specifically infect cancer cells and spread throughout tumors. I will discuss mathematical models applied to experimental data that analyze virus spread in a spatially structured setting, concentrating on the interactions of the virus with innate immune mechanisms that determine the outcome of virus spread.

Where

Emmy Noether Rm
Millikan 1021
Pomona College

__Claremont Graduate University__ | __Claremont McKenna__ | __Harvey Mudd__ | __Pitzer__ | __Pomona__ | __Scripps__

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