Multiphase flow modeling of cell adhesion and migration

When
Start: 03/07/2016 - 4:15pm
End  : 03/07/2016 - 5:15pm

Category
Applied Math Seminar

Speaker
Damir Khismatullin (Biomedical Engineering, Tulane U.)

Abstract

One of the fundamental properties of living cells is their ability to migrate from one region of space to another in response to specific chemical stimuli. Cell migration often involves adhesion to the surrounding tissue, chemoattractant-mediated intracellular signaling, and intracellular force generation. We have developed state-of-the-art three-dimensional computational algorithms, known as VECAM and VECAM-Active, to simulate cell-substrate adhesion and active, amoeboid migration of motile cells. These algorithms are based on the multiphase flow approach and account for cell and substrate deformability, rheological properties, multiple cellular compartments, receptor-ligand binding, transport of chemical activators (chemokines, cytokines), intracellular force generation due to actin polymerization, and physiologic shear flow conditions. In this talk, I will first present recent experimental data of my laboratory on circulating cell adhesion to activated vascular endothelium. Then I will show VECAM data on passive migration of cells in microchannels with different geometry (straight, Y-junction bifurcation, cross-flow, grooves and pillars), deformable cell adhesion to a receptor-coated substrate, and chemotactic and haptotactic migration of cells in a microchannel.

Where
Emmy Noether Room Millikan 1021 Pomona College