Stochastic Dynamics in Signal Transduction and Developmental Patterning

Start: 04/10/2013 - 1:15pm
End  : 04/10/2013 - 2:15pm

Applied Math Seminar

Qing Nie (Departments of Mathematics and Biomedical Engineering Center for Mathematical and Computational Biology Center for Complex Biological Systems University of California Irvine)


Noises and stochastic effects usually exist in every biological system
due to many intrinsic and extrinsic factors. In this talk, I will
discuss strategies and principles for noise attenuation and robustness
to genetic or/and environmental perturbations in cell signaling and
embryonic patterning. In one case, I will introduce a critical
quantity that dictates capability of attenuating temporal noises in
feedback systems. In another case, I will show that noises in
molecular signal transduction actually enable reduction of stochastic
effects in spatial patterns during embryonic development. In addition,
I will present several new experimental data in yeast cells and
zebrafish embryo that support our modeling and computational

RS 105