Understanding the regulation of stem cells through computational modeling

Start: 11/14/2012 - 1:15pm
End  : 11/14/2012 - 2:15pm

Applied Math Seminar

Vijay S Chickarmane (Division of Biology, Caltech)


A fascinating question is what are the mechanisms by which stem cells are maintained within a growing stem cell niche, while at the same time being a provider of a source of differentiated cells which are required for the development of the organism. Computational models of gene regulation and intracellular communication which describe some of these mechanisms will be discussed, with examples from plant and animal stem cells.  These models address how cells perceive and transduce external signals through a system of interacting feedback loops.  In this talk I will discuss how the dynamics of these regulatory circuits can help us understand how cells communicate and make decisions in the presence of cross-talk as well as within a noisy environment.

KRV 164

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