Mathematical modeling of drug release processes

Start: 09/26/2012 - 1:15pm
End  : 09/26/2012 - 2:15pm

Applied Math Seminar

Peter Hinow (UW, Milwaukee)


We focus on two drug delivery devices that are of interest to pharmaceutical scientists, liposomes and matrix tablets. Liposomes are microscopic spheres that consist of a lipid bilayer which can be loaded with a drug cargo. Bile salts can be used to modulate the permeability of the lipid bilayer for the drug molecules and thus to control their release. Matrix tablets are commonly formulated from powder mixtures where the pharmaceutically active drug is embedded in a matrix of inert excipient and polymers. These tablets are designed to release drug in a continuous fashion over an extended period of time. In collaboration with pharmaceutical scientists at the University of Otago, New Zealand and with Prof. Ami Radunskaya from Pomona College we have developed mathematical models that allow for a better understanding of these release processes. We use compartmental models of ordinary differential equations and cellular automata. Financial support has been provided by NSF grants DMS 1016214 and DMS 1016136.

KRV 164

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